Autonomia in the Anthropocene explores challenges posed to radical politics by an era of anthropogenic global change. Informed by new sites of struggle around extraction, waste, rising seas and toxic landscapes, and by new indigenous and worker movements, the issue rethinks key concepts in the autonomist lexicon -- species being, the common, multitude, potentia, the production of subjectivity -- in an effort to generate powerful analytical and political resources for confronting the social and ecological relations of informationalized capitalism.